In regards to the Artisan® 4 software program version, you are able to run it on either a 32-bit operating system or a 64-bit operating system of Windows Vista, 7, 8 or 10.
The 64-bit option and 32-bit option provide identical features and functions. The 64-bit option will generally run faster and provides better memory management capabilities though, but you can run it only if you have a 64-bit edition of Windows on your computer.
For the Artisan® 5 software program version, that is only compatible with a 64-bit edition of Windows 7, 8 or 10. This differentiation does not apply to the Artisan 5 upgrade version (which you can purchase if you have Artisan 4) and Artisan 5 full version (you must purchase this version if you never had Artisan 4).